Scientific Commons: Áine McKnight

HIV vaccines- a long road ahead (2007)

The diversity of HIV and its ease of escape from both cellular and humoral immune responsesare major obstacles to vaccine development. However, lessons from natural infectionand attenuated vaccine...

HIV-1 receptors and cell tropism (2001)

Clapham, Paul R, McKnight, Áine

HIV virus particles interact with several receptors on cell surfaces. Two receptors, CD4 and a co-receptor act sequentially to trigger fusion of viral and cellular membranes and confer virus entry...

Primary Human Immunodeficiency Virus Type 2 (HIV-2) Isolates Infect CD4-Negative Cells via CCR5 and CXCR4: Comparison with HIV-1 and Simian Immunodeficiency Virus and Relevance to Cell Tropism In Vivo

Reeves, Jacqueline D., Hibbitts, Sam, Simmons, Graham, McKnight, Áine, Azevedo-Pereira, José M., Moniz-Pereira, José, ...

Cell surface receptors exploited by human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) for infection are major determinants of tropism. HIV-1 usually requires two receptors to...

A Broad Range of Chemokine Receptors Are Used by Primary Isolates of Human Immunodeficiency Virus Type 2 as Coreceptors with CD4

McKnight, Áine, Dittmar, Matthias T., Moniz-Periera, José, Ariyoshi, Koya, Reeves, Jacqueline D., Hibbitts, Sam, ...

Like human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), HIV-2 requires a coreceptor in addition to CD4 for entry into cells. HIV and SIV coreceptor molecules belong...

CXCR4 as a Functional Coreceptor for Human Immunodeficiency Virus Type 1 Infection of Primary Macrophages

Simmons, Graham, Reeves, Jacqueline D., McKnight, Áine, Dejucq, Nathalie, Hibbitts, Sam, Power, Christine A., ...

The coreceptors used by primary syncytium-inducing (SI) human immunodeficiency virus type 1 isolates for infection of primary macrophages were investigated. SI strains using only CXCR4 replicated...

Characterization of a Late Entry Event in the Replication Cycle of Human Immunodeficiency Virus Type 2

McKnight, Áine, Griffiths, David J., Dittmar, Matthias, Clapham, Paul, Thomas, Elaine

Certain human cell lines and primary macrophage cultures are restricted to infection by some primary isolates of human immunodeficiency virus type 2 (HIV-2), although early steps of the viral life...

Blocking the docking of HIV-1

McKnight, Áine, Weiss, Robin A.

Lv2, a Novel Postentry Restriction, Is Mediated by both Capsid and Envelope

Schmitz, Christian, Marchant, David, Neil, Stuart J. D., Aubin, Keith, Reuter, Sandra, Dittmar, Matthias T., ...

The characterization of restrictions to lentivirus replication in cells identifies critical steps in the viral life cycle and potential therapeutic targets. We previously reported that a human...

Detection of Antibody-Dependent Complement-Mediated Inactivation of both Autologous and Heterologous Virus in Primary Human Immunodeficiency Virus Type 1 Infection†

Holuigue, Sophie, Aubin, Keith, Wong, MaiLee, Jones, Nicola A., Cornforth, David, ...

Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication. The...

The Promiscuous CC Chemokine Receptor D6 Is a Functional Coreceptor for Primary Isolates of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 on Astrocytes

Neil, Stuart J. D., Clapham, Paul R., Nibbs, Robert J., McKnight, Áine, Weiss, Robin A.

The role of coreceptors other than CCR5 and CXCR4 in the pathogenesis of human immunodeficiency virus (HIV) disease is controversial. Here we show that a promiscuous CC chemokine receptor, D6, can...

An Envelope-Determined, pH-Independent Endocytic Route of Viral Entry Determines the Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 to Lv2 Restriction

Marchant, David, Neil, Stuart J. D., Aubin, Keith, Schmitz, Christian, McKnight, Áine

We identified a postentry restriction, termed Lv2, which determines the cellular tropism of two related human immunodeficiency virus type 2 (HIV-2) isolates and is dependent on the sequence of the...

Identification of a Subset of Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus Strains Able To Exploit an Alternative Coreceptor on Untransformed Human Brain and Lymphoid Cells

Willey, Samantha J., Reeves, Jacqueline D., Hudson, Richard, Miyake, Koichi, Dejucq, Nathalie, Schols, Dominique, ...

The chemokine receptors CCR5 and CXCR4 are the major coreceptors for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). At least 12 other chemokine receptors or close...