| Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex | |||||||||||
Abstract | |||||||||||
| We used exploratory and confirmatory statistical approaches to study the severity of neuropsychological (NP) impairment in 42 crack/cocaine addicted subjects and in 112 comparison subjects (40 alcoholics and 72 controls). Twenty neuropsychological test indices most reliably defining predetermined cognitive domains were submitted to exploratory factor analysis. A four-dimensional model of neurocognitive function was derived: Verbal Knowledge, Visual Memory, Verbal Memory, and Attention/Executive functioning accounted for 63% of the variance. We then examined this model’s association with resting glucose metabolism in the brain reward circuit measured with 2-deoxy-2[18F]fluoro-d-glucose positron emission tomography. Results revealed that (1) cocaine addicted individuals had a generalized mild level of neurocognitive impairment ( | |||||||||||
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