| The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles | |||||||||||||
Abstract | |||||||||||||
| A survey of the Dictyostelium genome reveals at least 25 RasGEFs, all of which appear to be expressed at some point in development. Disruption of several of these novel RasGEFs reveals that many have clear phenotypes, suggesting that the unexpectedly large number of RasGEF genes reflects an evolutionary expansion of the range of Ras signaling. | |||||||||||||
Publication details | |||||||||||||
| |||||||||||||