| Cancer stem cells: Differentiation block or developmental back-tracking? (2006) | |||||||||
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| This author produced version paper published Seminars Cancer Biology This paper has been peer reviewed but does not include the final publisher proof corrections journal pagination Citation for the published paper Gisselsson Cancer stem cells Differentiation block developmental back tracking Seminars Cancer Biology Issue May http doi org semcancer Access the published version may require journal subscription Published with permission from Elsevier Editorial Cancer stem cells differentiation block developmental back tracking a well known curiosity that only minority cells within tumour are typically responsible for tumour growth and development Over the last few years has become possible isolate and characterise these tumour maintaining cells first from haematological malignancies and recently also from number solid tumours The fact that many the isolated tumour maintaining cells share surface markers with somatic stem cells and have capacities both self renewal and differentiation have popularly rendered them the name cancer stem cells Processes for isolation such cells are complex and some extent also controversial described several authors this issue Seminars Cancer Biology Park and Fan further illustrated the article Loda the identification such cells also depends understanding normal cell differentiation and the hierarchal relationships between tissue cells More than century ago was suggested that cancer cells originate from embryonic cell rests The concept cancer stem ce | |||||||||
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