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Cell-signalling dynamics in time and space (2006) |
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Abstract |
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The specificity of cellular responses to receptor stimulation is encoded by the spatial and temporal dynamics of downstream signalling networks. Computational models provide insights into the intricate relationships between stimuli and responses and reveal mechanisms that enable networks to amplify signals, reduce noise and generate discontinuous bistable dynamics or oscillations. These temporal dynamics are coupled to precipitous spatial gradients of signalling activities, which guide pivotal intracellular processes, but also necessitate mechanisms to facilitate signal propagation across a cell. |
Publication details |
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Cited publications (6) |
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Math. Control Signals Systems (2000) 13:41 62 2000 Springer-Verlag London Limited Mathematics of Control, Signals, and Systems (2003)
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Innovation, Changes of Techno-Economic Paradigm and Biological Analogies in Economics
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Signaling through Receptors and Scaffolds: Independent Interactions Reduce Combinatorial Complexity
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Mechanisms of Microtubule-Based Kinetochore Positioning in the Yeast Metaphase Spindle
- Sprague, Brian L.,
- Pearson, Chad G.,
- Maddox, Paul S.,
- Bloom, Kerry S.,
- Salmon, E. D.,
- Odde, David. J.
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Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation (2003)
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Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma.
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