| Expression of vascular endothelial growth factor and receptor flk-1 in colon cancer liver metastases (2004) | |||||||||||||||
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| J Hepatobiliary Pancreat Surg DOI Original articles Expression vascular endothelial growth factor and receptor colon cancer liver metastases Jun Cheng Richard Slavin Jennifer Gallagher Guojing Zhu Thomas Biehl Lee Swanstrom and Paul Hansen General Surgery University Michigan Health System Medical Center Ann Arbor USA Legacy Health System Portland USA Virginia Mason Medical Center Seattle USA Abstract Background Purpose This study investigated vascular endothelial growth factor VEGF and expression hepatic metastases from colon carcinoma and their associations with tumor angiogenesis proliferation and apoptosis Methods Immunohistochemical studies were performed for VEGF and bcl expression and microvessel density MVD surgical specimens from patients who underwent hepatectomy for colon cancer liver metastases between and Results VEGF and were expressed mainly the cytoplasm tumor cells High VEGF expression was associated with high expression MVDs less than and more were found and hepatic metastases respectively index more was detected tumors and these showed more less than was present tumors The expression VEGF was related elevated MVD VEGF was also associated with increased Mutant and bcl expressions were detected and liver metastases respectively Mutant was not related VEGF expression but bcl was highly associated with The incidences high expression and more were signi cantly higher tumors which were both and bcl positive and than tumors which were negative for both and Conclusi. Peer Reviewed. http://deepblue.lib.umich.edu/bitstream/2027.42/41588/1/534_2003_Article_883.pdf | |||||||||||||||
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