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Apparent synergism between amino donors for CTP synthesis in Chinese hamster fibroblasts (1983)

Abstract

The synergistic effects of potential amino donors were studied in the assay of CTP synthetase in extracts of Chinese hamster fibroblasts. We found that L-glutamine was not effective as the sole amino donor, but combinations of L-glutamine with NH 4 HCO 3 , L-arginine or potassium phosphate did result in the conversion of UTP to CTP. L-arginine or potassium phosphate were also not effective when used alone, and NH 4 HCO 3 was only slightly effective. Our studies demonstrate that the individual synergistic combinations were not additive; multiple combinations of components decreased rather than increased the formation of CTP.. Peer Reviewed. http://deepblue.lib.umich.edu/bitstream/2027.42/45347/1/11010_2004_Article_BF00223531.pdf

Publication details

Download	, http://hdl.handle.net/2027.42/45347 http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6656747&dopt=citation
Publisher	Kluwer Academic Publishers; Martinus Nijhoff Publishers ; Springer Science+Business Media
Contributors	Department of Human Genetics, University of Michigan Medical School, 48109, Ann Arbor, MI, USA, Department of Human Genetics, University of Michigan Medical School, 48109, Ann Arbor, MI, USA, Ann Arbor
Repository	University of Michigan (United States)
Keywords	Life Sciences, Medical Biochemistry, Biochemistry, general, Oncology, Cardiology, Public Health, Biological Chemistry, Science, Health Sciences
Language	English

Publications citing this publication (1)

The kinetics and feedback inhibition of cytidine 5′-triphosphate synthetase in wild-type and mutant Chinese hamster cells (1984)