| Chemokines in rheumatoid arthritis (1998) | |||||||||||||
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| Springer Semin Immunopathol Springer Seminars Immunopathology Springer Verlag Chemokines rheumatoid arthritis Zoltan k c Robert Strieter Steven n Alisa c Department Medicine Section Arthritis and Connective Tissue Diseases Northwestern University Medical School Department Medicine Chicago Avenue Ward Building Chicago USA Department Medicine The University Michigan Medical Center Ann Arbor USA Department Pathology The University Michigan Medical Center Ann Arbor USA Veteran Administration Lakeside Medical Center Chicago USA Third Department Medicine University Medical School Debrecen Hungary Introduction Rheumatoid arthritis systemic chronic inflammatory disease with prevalence the population the synovial tissue invaded inflammatory cells These leukocytes and their products play essential role synovitis pannus formation and eventually joint destruction Cytokines are mediators involved the inflammatory events underlying The chemokine family consists number distinct cytokines with structural homology These proteins have potent chemotactic activity for cells the immune system and they appear play particularly important role both the destructive and the fibrovasculoproliferative phase reviewed Among cells present the synovium macrophages are major source chemokines Many these chemokines are also involved associated angiogenesis the formation new blood vessels the inflamed synovium reviewed Clinical management often difficult and includes long term use immunosuppressants There are . http://deepblue.lib.umich.edu/bitstream/2027.42/46938/1/281_2004_Article_BF00832002.pdf | |||||||||||||
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