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Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition (TPN) (2004)

Abstract

Lipids are an important component of total parenteral nutrition (TPN), contributing the largest caloric load per volume of solution and providing essential fatty acids necessary for survival. However, lipids are known to be causative factors in oxidative stress, which are expressed via the Bcl-2 family of proteins and/or Fas-mediated apoptosis in several tissues. Interestingly, we have recently observed an increase in hepatocyte apoptosis with administration of TPN. To address the mechanism of this apoptosis, we investigated the effects of parenteral lipid administration on apoptotic signaling in a mouse model. C57BL/6J male mice received physiologic saline and standard chow (control) or standard TPN solution with (TPN+L) or without lipid (TPN-L) emulsion. After 7 days of infusion, apoptosis increased in the TPN+L at a significantly higher rate compared with control and TPN-L groups ( p . Peer Reviewed. http://deepblue.lib.umich.edu/bitstream/2027.42/47162/1/383_2003_Article_1115.pdf

Publication details

Download	, http://hdl.handle.net/2027.42/47162 http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15034728&dopt=citation
Publisher	Springer-Verlag
Contributors	Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, F3970 Mott Children’s Hospital, Ann Arbor, MI , 48109-0245 , USA, Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, F3970 Mott Children’s Hospital, Ann Arbor, MI , 48109-0245 , USA, Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, F3970 Mott Children’s Hospital, Ann Arbor, MI , 48109-0245 , USA, Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, F3970 Mott Children’s Hospital, Ann Arbor, MI , 48109-0245 , USA, Pharmacy Department, University of Michigan Medical School, Mott Children’s Hospital, Ann Arbor, MI, USA, Ann Arbor
Repository	University of Michigan (United States)
Keywords	Lipid, Total parenteral nutrition (TPN), Hepatocyte, Medicine, Apoptosis, Pediatrics, Health Sciences
Type	Original Article
Language	English

Cited publications (3)

The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites (2001)

Bid, a Widely Expressed Proapoptotic Protein of the Bcl-2 Family, Displays Lipid Transfer Activity

Total parenteral nutrition-induced apoptosis in mouse intestinal epithelium: regulation by the Bcl-2 protein family (2002)