| Single or multiple familial cognitive risk factors in schizophrenia? (2001) | |||||||||
Abstract | |||||||||
| American Journal Medical Genetics Neuropsychiatric Genetics Single Multiple Familial Cognitive Risk Factors Schizophrenia Department Psychiatry and Neuropsychology Maastricht University European Graduate School Neuroscience Maastricht The Netherlands Institute Psychiatry London Lydia Krabbendam Machteld Marcelis Philippe Delespaul Jelle Jolles and Jim van The fact that relatives patients with schizophrenia display subtle cognitive abnormalities suggests genetic transmission underlying cognitive endophenotype was examined what extent the cognitive abnormalities that discriminate patients and relatives from controls independently each other and independent Neuropsychological measures were assessed patients with schizophrenia rst degree relatives patients with schizophrenia and healthy controls The assessment focused episodic memory attentional span simple and complex speed information and semantic memory Factor analysis the cognitive test results yielded four factors ecting speed episodic memory working memory and semantic uency Performance the relatives was intermediate that the patients and the controls after adjustment for age sex educational level and For both patients and relatives speed information processing working memory and episodic memory independently discriminated from control performance with similar pattern the order the size the effects The results suggest the existence more than one familial cognitive risk factor for schizophrenia Independent familial cognitive | |||||||||
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Cited publications (2) | |||||||||
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