| HTLV-III: Intra-BBB IgG Synthesis and Hybridization in CSF Cells. (1998) | |||||||||
Abstract | |||||||||
| HIV is a pathogenic retrovirus which causes a progressive deterioration of the immune system and is associated with a wide variety of human diseases. Neurological disease is a major problem in the HIV infected population. The purpose of this proposal is to understand the natural history of HIV associated neurological disease. Opportunistic infections and tumors of the central nervous system (CNS) were the first neurological disease reported in HIV infected patients. Subsequently, the most common neurological diseases reported in HIV infected patients. Subsequently, the most common neurologic manifestation of HIV was found to be a subacute encephalopathy characterized by cognitive deficits, motor slowing, and behavioral changes, called the 'AIDS Dementia Complex (ADC)'. The spectrum of ADC ranges from mild cognitive abnormalities on neuropsychologic testing in otherwise asymptomatic individuals to a bedridden state marked by global dementia, severe hypokinesis, mutism, incontinence, and seizures. To this date, only HIV has been consistently implicated as the etiologic agent in ADC. | |||||||||
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