| Absence of Mutagenic Activity of Hycanthone in Serratia marcescens, (2002) | |||||||||
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| Hycanthone methanesulfonate, an antischistosomal agent, is an effective frameshift mutagen in Salmonella typhimurium but did not induce auxotrophic mutations in Serratia marcescens HY, even at high concentrations (25,000 ug/ml). The mutagenic action of hycanthone in S. typhimurium is not dependent on a functional excision repair system but is enhanced by the plasmid pKM101, which mediates the inducible error-prone repair system. Hycanthone, like proflavin, intercalates between the stacked bases of DNA. Upon replication, DNA lesions are generated which induce error-prone repair. It is suggested that s. marcescens HY is insensitive to the mutagenic action of hycanthone because it lacks an error-prone repair system. | |||||||||
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