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Elevated mutation rate in mutT bacteria during starvation: evidence for DNA turnover?

Abstract
The rate of appearance of prototrophic revertants when Escherichia coli tyrA14 (ochre) or trpA23 bacteria were incubated on plates lacking the required amino acid was greatly elevated when the organisms also carried a mutT mutation. One possible explanation for this result is that the amount of DNA replication or turnover under these conditions is much greater than has been previously recognized.

Publication details
Download http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=177999
Repository PubMed Central (PMC3 - NLM DTD) (United States)
Keywords Research Article
Type Text
Language Englisch