| Linkage Disequilibrium Mapping of Quantitative-Trait Loci by Selective Genotyping | |||||||||||||
Abstract | |||||||||||||
| The principles of linkage disequilibrium mapping of dichotomous diseases can be well applied to the mapping of quantitative-trait loci through the method of selective genotyping. In 1999, M. Slatkin considered a truncation selection (TS) approach. We propose in this report an extended TS approach and an extreme-rank-selection (ERS) approach. The properties of these selection approaches are studied analytically. By using a simulation study, we demonstrate that both the extended TS approach and the ERS approach provide remarkable improvements over Slatkin’s original TS approach. | |||||||||||||
Publication details | |||||||||||||
| |||||||||||||