| The Exotoxin of P. aeruginosa: A Proenzyme Having an Unusual Mode of Activation (2006) | |||||||||||
Abstract | |||||||||||
| The exotoxin of Pseudomonas aerguinosa is a proenzyme possessing latent ADPR-transferase activity. Conversion to the active form can be effected by simultaneous treatment with a protein denaturant and a chemical able to split disulfide bonds. Activation results from a conformational change that exposes the previously buried active site. Proteolysis is not required. | |||||||||||
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