| Molecular Descriptors Family on Structure Activity Relationships 5. Antimalarial Activity of 2,4-Diamino-6-Quinazoline Sulfonamide Derivates (2006) | |||||||
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| Antimalarial activity of sixteen 2,4-diamino-6-quinazoline sulfonamide derivates was modeled using an original methodology which assess the relationship between structure of compound and theirs activity. The results shows us that the antimalarial activity of studied 2,4-diamino-6-quinazoline sulfonamide compounds is alike topological and geometrical and is strongly dependent on partial change of the molecule. The ability in prediction with SAR models is sustained by the results obtained through cross-validation analysis and by the stability of the models. The SAR methodology gives us a real solution in structure-activity relationships investigation of 2,4-diamino-6-quinazoline sulfonamide compounds, obtaining better results by the use of two and/or three descriptors compared with the best performing previous reported model. Keywords Structure - Activity Relationships (SAR), Molecular Descriptors Family (MDF), Multiple Linear Regression (MLR), Antimalarial Activity, 2,4-diamino-6-quinazoline sulfonamide derivates | |||||||
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