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Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain |
- Lee, Jeffrey C,
- Vivanco, Igor,
- Beroukhim, Rameen,
- Huang, Julie H. Y,
- Feng, Whei L,
- DeBiasi, Ralph M,
- Yoshimoto, Koji,
- King, Jennifer C,
- Nghiemphu, Phioanh,
- Yuza, Yuki,
- Xu, Qing,
- Greulich, Heidi,
- Thomas, Roman K,
- Paez, J. Guillermo,
- Peck, Timothy C,
- Linhart, David J,
- Glatt, Karen A,
- Getz, Gad,
- Onofrio, Robert,
- Ziaugra, Liuda,
- Levine, Ross L,
- Gabriel, Stacey,
- Kawaguchi, Tomohiro,
- O'Neill, Keith,
- Khan, Haumith,
- Liau, Linda M,
- Nelson, Stanley F,
- Rao, P. Nagesh,
- Mischel, Paul,
- Pieper, Russell O,
- Cloughesy, Tim,
- Leahy, Daniel J,
- Sellers, William R,
- Sawyers, Charles L,
- Meyerson, Matthew,
- Mellinghoff, Ingo K
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Abstract |
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Ingo Mellinghoff and colleagues sequenced theEGFR gene in glioblastoma samples and cell lines and identified missense mutations in the extracellular domain that suggest a new mechanism for EGFR activation. |
Publication details |
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