| Lovastatin Induces Relaxation and Inhibits L-Type Ca2+ Current in the Rat Basilar Artery. (2003) | |||||||||
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| C Pharmacology Toxicology Printed Denmark All rights reserved Copyright ISSN Lovastatin Induces Relaxation and Inhibits Type Current the Rat Basilar Artery Andreas Bergdahl Erik Persson Per Hellstrand and Karl Division Molecular and Cellular Physiology Department Physiological Sciences Lund University Biomedical Center BMC Lund Sweden Received January Accepted May Abstract Statins inhibit cholesterol biosynthesis and protect against ischaemic stroke has become increasingly apparent that the beneficial effects statin therapy may extend beyond lowering serum cholesterol The present study was done explore possible pleiotropic statin effects the level the cerebral vascular smooth muscle Lovastatin lovastatin acid simvastatin and pravastatin were added segments the rat basilar artery and effects contraction and handling were examined Pravastatin had effect contraction Simvastatin lovastatin and lesser degree lovastatin acid caused relaxation and mmol both intact and denuded arteries precontracted with high This effect was not reversed mevalonate suggesting that was not related cholesterol isoprenoid metabolism Relaxation was associated with reduction the intracellular concentration measured with Fura and with reduced quench rate suggesting direct effect ion channels the smooth muscle cell membrane Current measurements isolated and voltage clamped basilar artery muscle cells demonstrated that both lovastatin and lovastatin acid inhibit type current propose that lipophilicity import | |||||||||
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Cited publications (2) | |||||||||
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