| Role of cell therapy in Parkinson disease. (2002) | |||||||||
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| Neurosurg Focus Article Click here return Table Contents Role cell therapy Parkinson disease OLLE LINDVALL D AND PETER HAGELL D Section Restorative Neurology Wallenberg Neuroscience Center University Hospital Lund Sweden Clinical studies involving intrastriatal transplantation embryonic mesencephalic tissue patients with Parkinson disease have provided proof principle for the cell replacement strategy this disorder The grafted dopaminergic neurons can reinnervate the denervated striatum restore regulated dopamine release and movement related frontal cortical activation and produce significant symptomatic relief the most successful cases patients have been able withdraw from levodopa treatment after undergoing transplantation and resume independent life There are however several problems linked the use primary embryonic tissue lack sufficient amounts tissue for transplantation large number patients variability functional outcome major improvement some and modest any clinical benefit others and occurrence troublesome dyskinesias significant proportion patients after transplantation Thus neural transplantation still experimental stage the treatment For the development clinically useful cell therapy need define better criteria for patient selection and how graft placement should optimized each individual Most importantly need generate large numbers viable dopamine neurons preparations that are standardized and quality controlled Stem cells could useful unlimited source dopamine n | |||||||||
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