| Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity. (2005) | |||||||||
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| The following pages constitute the final accepted and revised manuscript the article Structural and numerical chromosome changes colorectal cancer develop through telomere mediated anaphase bridging and not through mitotic multipolarity Ylva Stew nius Ludmila Gorunova Tord Jonson Nina Larsson Mattias glund Nils Mandahl Fredrik Mertens Felix Mitelman and David Gisselsson Proc Natl Acad Sci Apr Publisher National Academy Sciences Use alternative location the published version the article requires journal subscription Alternative location http doi org pnas Biological Sciences Medical Sciences Structural and numerical chromosome changes colorectal cancer develop through telomere mediated anaphase bridging and not through mitotic multipolarity Ylva Stew nius Ludmila Gorunova Tord Jonson Nina Larsson Mattias glund Nils Mandahl Fredrik Mertens Felix Mitelman and David Gisselsson Department Clinical Genetics University Hospital Lund Sweden Text pages Figures Tables Words Abstract Total number characters text Abbreviations ABF anaphase bridge frequency BFB breakage fusion bridge CIN chromosomal instability FISH fluorescence situ hybridization MIN microsatellite instability multipolar mitosis TDT terminal deoxynucleotidyl transferase TFI telomere fluorescence intensity whom reprint requests should addressed mail david gisselsson klingen Abstract Telomere dysfunction has been associated with chromosomal instability CIN colorectal carcinoma but the consequences telomere dependent instabi | |||||||||
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