| Error models for microarray intensities (2004) | |||||||||||
Abstract | |||||||||||
| We derive the additive-multiplicative error model for microarray intensities, and describe two applications. For the detection of differentially expressed genes, we obtain a statistic whose variance is approximately independent of the mean intensity. For the post hoc calibration (normalization) of data with respect to experimental factors, we describe a method for parameter estimation. | |||||||||||
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