| Differential recognition of the serologically defined HLA-A2 antigen by allogeneic cytotoxic T cells. (1982) | |||||||||
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| IAO LMUHUilO Immunogenenci genetics Springet Verlag Differential Recognition the Serologically Defined HLA Antigen Allogeneic Cytotoxic Cells Population Studies Satoshi Horai Jan van der Poel and Eis Goulmy Department Anthropology Faculty Science The University Tokyo Tokyo Japan Department Immunohaematology and Blood Bank University Hospital Leiden the Netherlands Abstract Human alloimmune cytotoxic cells sensitized selectively against the HLA antigen were tested panel selected target cells Five HLA positive outlier cells could ldentified These outlier cells were only weakly lysed HLA specific CTLs although they were serologically indistinguishable from the other HLA positive strongly lysed target cells Furthermore was found that the outlier cells were poor cold target inhibitors contrast the other HLA positive target cells which showed adequate Inhibition specific lysis HLA positive target cells Population studies indicate that the frequency such HLA outlier cells may approximately Introduction generally accepted that gene products the major histocompatibility complex MHC play important role cell mediated lympholysis CML both the induction phase and the recognition phase allogeneic cytotoxic lymphocytes CTLs The antigens recognized allogeneic CTLs were initially shown the serologically defined HLA and antigens Miggiano Eijsvoogel Grunnet but also the HLA region products were proven target antigens Mawas Albrechtsen Feighery and Stastny Johnsen Apart from the serologically de | |||||||||
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