| Photopolymerization of diacetylene lipid bilayers and its application to the construction of micropatterned biomimetic membranes (2002) | |||||||||||
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| Photopolymerization Diacetylene Lipid Bilayers and Its Application the Construction Micropatterned Biomimetic Membranes Kenichi Morigaki Tobias Baumgart Ulrich Jonas Andreas Offenha usser and Wolfgang Knoll Max Planck Institut Polymerforschung Ackermannweg Mainz Germany Received December Final Form March Photopolymerization diacetylene containing amphiphiles substrate supported bilayers has been studied connection with the development new fabrication strategy micropatterned biomimetic membrane systems Two types amphiphilic diacetylene molecules were compared one being monoalkyl phosphate phosphoric acid monohexacosa diynyl ester and the other being phospholipid bis tricosadiynoyl glycero phosphocholine The bilayers monomeric diacetylene amphiphiles were deposited onto substrates the Langmuir Blodgett Langmuir Schaefer methods Both amphiphiles could polymerized successfully oxide and polymer coated substrates However the phospholipid showed markedly higher mechanical stability the polymerized bilayer films compared with the monoalkyl phosphate Micropatterns were imposed the bilayers using physical mask protect the monomeric lipids partially upon irradiation the case monomeric bilayers couldberemovedselectivelybyethanolafterthelithographicphotopolymerization resultingintheformation wells between the polymerized bilayers These wells were filled with fluid phosphatidylcholine bilayers fusion vesicles The rigid polymeric bilayer and the fluid biomimetic bilayer could integrated co | |||||||||||
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