| Lipid vesicle fusion on µCP patterned self-assembled monolayers : effect of pattern geometry on bilayer formation (2002) | |||||||||||
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| Lipid Vesicle Fusion Patterned Self Assembled Monolayers Effect Pattern Geometry Bilayer Formation Toby Jenkins Richard Bushby Stephen Evans Wolfgang Knoll Andreas Offenha usser and Simon Ogier Department Chemistry University Bath Bath Centre for Self Organising Molecular Systems University Leeds Leeds Max Planck Institut Polymerforschung Ackermannweg Mainz Germany and Forschungszentrum lich lich Germany Received October Final Form January Microcontact printing lipophilic self assembled monolayers SAMs has been used fabricate micron dimensioned patterned surfaces that can used means attaching lipid bilayers solid surfaces This communication addresses how variation the patterned SAM geometry affects vesicle adsorption The substrates consisted circular hydrophilic regions functionalized with mercaptoethanol surroundedbyoctadecanethiol ODT Threegeometrieswerestudiedinwhichthediameterofthehydrophilic portion was varied between and and the center center separation was varied between and Thus was possible study lipid adsorption SAM systems with the same total hydrophilic surface area but with different sized hydrophilic patches Impedance spectroscopy showed that for the films the same total hydrophilic area greater lipid coverage was obtained for SAMs with smaller diameter hydrophilic patches understand this observation tapping mode AFM and surface plasmon microscopy were used study lipid vesicles adsorption such surfaces new mode vesicle adsorption micropatterned hydrophobic hydro | |||||||||||
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