| Polysaccharide-supported planar bilayer lipid model membranes (2003) | |||||||||||
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| Langmuir Polysaccharide Supported Planar Bilayer Lipid Model Membranes Tobias Baumgart and Andreas Offenhausser Max Planck Institute for Polymer Research Ackermannweg Mainz Germany Received June Final Form September Bilayer lipid membranes were deposited onto two different thin water swellable polymer cushions predominantly Langmuir Blodgett trough methods Membranes consisting zwitterionic lipids supported agarose films were shown unstable observed fluorescence microscopy reflection interference contrast microscopy and the impossibility bilayer spreading Radler Strey Sackmann Langmuir the agarose surface Chitosan formerly observed permanently coat liposome surfaces zwitterionic lipid membranes Henriksen Smistad Karlsen Int Pharm was used prepare thin films spin coating and was found sufficiently adsorb and thereby stabilize planar bilayer lipid membranes Bilayer spreading chitosan surface was observed indicating the self healing ability chitosan supported lipid membranes Introduction Polymer interlayers have great potential for effectively decoupling lipid membranes and the peripheral parts integral membrane proteins from supports such glass gold indium tin oxide ITO silicon devices Therefore numerous efforts have been made prepare suitable polymer cushions physisorbed chemically coupled underlying support and physisorbed chemically coupled the lipid membrane top Lipid membranes that are either completely partially chemically coupled the polymer cushion are regarded advantage | |||||||||||
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