| Suspended Nanoporous Membranes as Interfaces for Neuronal Biohybrid Systems (2006) | |||||||||||
Abstract | |||||||||||
| NANO LETTERS Suspended Nanoporous Membranes Interfaces for Neuronal Biohybrid Systems Bernhard Wolfrum Yulia Mourzina Frank Sommerhage and Andreas Offenhausser ISG Institute for Thin Films and Interfaces Center Nanoelectronic Systems for Information Technology Research Center Juelich Juelich Germany Received December Revised Manuscript Received January Vol ABSTRACT biohybrid system composed neuronal cells and silicon supported nanoporous membranes has been designed facilitate control the biochemical environment neuronal networks with cellular resolution The membranes may exhibit variable pore sizes and interpore distances and are interfaced microfluidic device Different porosity parameters give rise changes the transconductance the nanopores and can therefore used control diffusion molecules through the membranes was shown that the porous membranes are biocompatible with primary vertebrate well insect neurons Our results indicate that nanoporous membranes may used interface with biological materials biohybrid system for example artificial chemical synapse interface With the development biosensors and neuroprosthetic devices biohybrid systems are starting gain lot attention Important aspects for many cell based biohybrid systems are the biocompatibility the interfacing substrate well the functional coupling between biological and artificial materials Nanoporous materials offer new possibilities biointerfaces and may used biomedical applications For example nanoporous alumina p | |||||||||||
Publication details | |||||||||||
| |||||||||||