| New haplotype sharing and haplotype assignment methods for mapping genes of complex diseases (2004) | |||||||||||||||
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| Lars Beckmann hum New haplotype sharing and haplotype assignment methods for mapping genes complex diseases Geboren Melle Niedersachsen Diplom der Fachrichtung Mathematik der Universit ln Promotionsfach DKFZ Deutsches Krebsforschungszentrum Doktormutter Priv Doz hum Chang Claude The major focus genetic epidemiology identify and characterize genes that are involved the etiology and pathogenesis common complex diseases The findings relevant genes will lead progress prevention the population level well the individual level and improvement diagnosis and therapy The overall topic the thesis the exploration and further development haplotype sharing methods map genes involved the etiology complex disease The potential value haplotypes has attracted widespread interest the mapping complex traits Haplotype sharing methods take the linkage disequilibrium information between multiple markers into account and have more power detect predisposing genes compared with single point linkage association methods The aims the thesis are threefold First the haplotype sharing statistics HSS investigated the context complex diseases using simulated data under varying conditions such different sample sizes marker characteristics haplotype assignment and population characteristics Secondly new approach which based the Mantel statistics for space time clustering developed order improve the power haplotype sharing analysis The new statistic correlate genetic similarity and phenotypic similarity for case | |||||||||||||||
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