| Optimal length and signal amplification in weakly activated signal transduction cascades (2003) | |||||||||
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| Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for the propagation of the input signal down the cascade and for the characterization of the final outcome. The most efficient design of a cascade for generating sharp signals, is obtained by choosing all the off rates equal, and a ``universal'' finite optimal length.. Comment: 27 pages, 10 figures, LaTeX file | |||||||||
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