| The Arabidopsis HOBBIT gene encodes a CDC27 homolog that links the plant cell cycle to progression of cell differentiation (2002) | |||||||||||||
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| Downloaded from www genesdev org April The Arabidopsis HOBBIT gene encodes CDC homolog that links the plant cell cycle progression cell differentiation Ikram Blilou Florian Frugier Saskia Folmer Olivier Serralbo Viola Willemsen Harald Wolkenfelt Nubia Eloy Paulo Ferreira Peter Weisbeek and Ben Scheres Department Molecular Cell Biology Utrecht University Utrecht The Netherlands Departmento Bioqu mica Medica Universidade Federal Rio Janeiro Rio Janeiro Brasil plant meristems dividing cells interpret positional information and translate into patterned cell differentiation Here report the molecular identification the Arabidopsis HOBBIT gene that required for cell division and cell differentiation meristems show that encodes homolog the CDC subunit the anaphase promoting complex APC HOBBIT partially complements yeast nuc cdc mutant Unlike other CDC homologs Arabidopsis its transcription cell cycle regulated Furthermore hobbit mutants show reduction GUS auxin reporter gene expression and accumulate the AXR IAA repressor auxin responses HOBBIT activity may thus couple cell division cell differentiation regulating cell cycle progression the meristem restricting the response differentiation cues such auxin dividing cells Keywords APC auxin BimA meristem Nuc pattern formation Received May revised version accepted July Meristems higher plants are postembryonic regions mitotic activity that continuously produce new cells Steeves and Sussex These cells interpret positional cues for fate d | |||||||||||||
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