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Application of phage display to high throughput antibody generation and characterization |
- Schofield, Darren J,
- Pope, Anthony R,
- Clementel, Veronica,
- Buckell, Jenny,
- Chapple, Susan DJ,
- Clarke, Kay F,
- Conquer, Jennie S,
- Crofts, Anna M,
- Crowther, Sandra RE,
- Dyson, Michael R,
- Flack, Gillian,
- Griffin, Gareth J,
- Hooks, Yvette,
- Howat, William J,
- Kolb-Kokocinski, Anja,
- Kunze, Susan,
- Martin, Cecile D,
- Maslen, Gareth L,
- Mitchell, Joanne N,
- O'Sullivan, Maureen,
- Perera, Rajika L,
- Roake, Wendy,
- Shadbolt, S Paul,
- Vincent, Karen J,
- Warford, Anthony,
- Wilson, Wendy E,
- Xie, Jane,
- Young, Joyce L,
- McCafferty, John
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Abstract |
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A phage display library has been constructed containing over 1010 human antibodies, allowing the large-scale generation of antibodies. Over 38,000 recombinant antibodies against 292 antigens were selected, screened and sequenced, and 4,400 resultant unique clones characterized further. |
Publication details |
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