| Parameterization of population balance models for polythermal auto seeded "preferential crystallization" of enantiomers (2007) | |||||||||
Abstract | |||||||||
| For analysis, design and model based control of crystallization processes typically population balance models are used. Usually the kinetic parameters in these models are determined analyzing measured concentration trajectories and/or particle size distributions using parameter estimation procedures. In the case of preferential crystallization ofenantiomers analysis of corresponding experiments is complex since there are two “competing” crystal populations. In this field often batch processes are performed using seeds of the desired enantiomer. Currently it is in particular challenging to quantify and optimize a new concept: The so called “auto seeded programmed polythermal preferential crystallization” (“AS3PC” (Coquerel et al. 2000)). In order to optimize this non isothermal process the temperature dependent kinetic constants for crystal growth, nucleation and dissolution have to be estimated. In this work a design of experiments was applied in order to estimate those parameters for a case study. | |||||||||
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