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Untangling the signalling wires (2007)

Kholodenko, Boris N.

Abstract

Mitogen-activated protein kinase (MAPK) cascades process myriads of stimuli, generating receptor-specific cellular outcomes. New work exploits emergent mathematics of network inference to reveal distinct feedback designs of the RAF/MEK/ERK cascade induced by two different growth factors. It shows that response specificity can arise from differential signal-induced wiring of overlapping protein networks.

Publication details

Download	http://jdc.jefferson.edu/pacbfp/17
Publisher	Jefferson Digital Commons
Repository	Jefferson Digital Commons (United States)
Keywords	cell differentiation, cell proliferation, epidermal growth factor, Extracellular Signal-Regulated MAP Kinases, biochemical feedback, genetics, metabolism, Intercellular Signaling Peptides and Proteins, biological models, MAP Kinase Signaling System, nerve growth factor, Mitogen-Activated Protein Kinase Kinases, physiology, PC12 Cells, rats, small interfering RNA, phosphorylation, Protein Kinase C-delta, raf Kinases
Type	text