| Hydrogen bonding in pyrimethamine hydrogen adipate (2007) | |||||||||
Abstract | |||||||||
| In 2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidinium hydrogen adipate, $C_{12}H_{14}ClN_4^+.C_6H_9O_4_^-$, the protonated pyrimethamine cation interacts with the carboxylate group of the adipate ion through $N-H^{...}O$ hydrogen bonds, forming a cyclic hydrogen-bonded $R_2^2(8)$ motif. The carboxyl and carboxylate groups of the adipate ions are linked through $O-H^{...}O$ hydrogen bonds in a head-to-tail fashion, forming a chain. Anions and cations are further connected by an extensive network of $N-H^{...}O$ hydrogen bonds. | |||||||||
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