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Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting (2006)

Abstract
There are proposals for the implementation of beta(2)-adrenoceptor agonists for the management of muscle wasting diseases. The idea has been initiated by studies in animal models which show that beta(2)-adrenoceptor agonists cause hypertrophy of skeletal muscle. Their use in clinical practice will also need an understanding of possible effects of activation of human heart beta(2)-adrenoceptors. Consequences could include an increased probability of arrhythmias in susceptible patients.

Publication details
Download http://espace.library.uq.edu.au/view/UQ:82735
Publisher Nature Publishing Group
Repository ARROW Discovery Service (Australia)
Keywords Basic Pharmacology (320502), Cardiovascular system and diseases (730106), Pharmacology & Pharmacy, Skeletal Muscle, Muscle Wasting, Human Heart, Arrhythmias, Beta()-adrenoceptor (2), Formoterol, Salmeterol, Chronic Heart-failure, Rat Skeletal-muscles, Ventricular Myocardium, Cardiovascular Safety, Troponin-i, Receptor, Hypertrophy, Salbutamol, Relaxation
Type journal article
Relation isMemberOf School of Medicine Publications