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Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients (2007) |
- McMorran, B. J.,
- Patat, S. A. O.,
- Carlin, J. B.,
- Grimwood, K.,
- Jones, A.,
- Armstrong, D. S.,
- Galati, J. C.,
- Cooper, P. J.,
- Byrnes, C. A.,
- Francis, P. W.,
- Robertson, C. F.,
- Hume, D. A.,
- Borchers, C. H.,
- Wainwright, C. E.,
- Wainwright, B. J.
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Abstract |
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Background: Airway inflammation in cystic fibrosis (CF) is exaggerated and characterized by neutrophilmediated tissue destruction, but its genesis and mechanisms remain poorly understood. To further define the pulmonary inflammatory response, we conducted a proteome-based screen of bronchoalveolar lavage fluid (BALF) collected from young children with and without CF experiencing endobronchial infection. Methods: We collected BALF samples from 45 children younger than 5 years and grouped them according to the presence of respiratory pathogens: >= 1 X 10(5) colony forming units (CFU)/mL BALF (18 and 12 samples with and without CF, respectively) and |
Publication details |
| Download |
http://espace.library.uq.edu.au/view/UQ:130219 |
| Publisher |
American Association for Clinical Chemistry
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| Repository |
ARROW Discovery Service (Australia) |
| Keywords |
Genetics not elsewhere classified (270299),
Biological sciences (780105),
Medical Laboratory Technology,
Bronchial Epithelial-cells,
Lower Airway Inflammation,
Cytokine Production,
Pseudomonas-aeruginosa,
Pulmonary Infections,
Alpha-defensin,
Lung-disease,
Infants,
Identification,
Elastase
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| Type |
journal article
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| Relation |
isMemberOf 2008 Higher Education Research Data Collection,
isMemberOf Journal Article Import (ISI/CVs),
isMemberOf Institute for Molecular Bioscience - Publications,
isMemberOf Excellence in Research Australia (ERA) - Collection
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