| Role of nitric oxide in the pathogenesis of shigellosis and cholera in children (2007) | |||||||||||||
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| Objective: Evaluate the role of nitric oxide in the pathogenesis of shigeltosis and cholera in children. Methodology: Concentrations of nitrite, a stable metabolite of nitric oxide (by Griess reaction) in urine and serum samples of 24 patients aged 1-5 years (10 shigellosis, 14 cholera) were determined. Tests were done on admission to hospital with acute diarrhoea and repeated at early convalescence after 3-7 days of specific antimicrobial therapy. Results: In children with shigellosis, urinary nitrite excretion (nM/mg creatinine) was significantly increased during acute illness compared to early convalescence, median (range): 7061 (1046-18264) vs. 4316 (2369-12428. p | |||||||||||||
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