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Design and synthesis of phosphotyrosine mimetics (2003) |
- Yan, Zheng,
- Kahn, Michael,
- Qabar, Maher,
- Urban, Jan,
- Kim, Hwa-Ok,
- Blaskovich, Mark
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Abstract |
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Selective inhibitors of protein tyrosine phosphatases (PTPases) are of great interest as therapeutic agents and research tools. Several phenylalanine derivatives (1, 2) designed as phosphotyrosine mimetics or irreversible active site inhibitors were successfully synthesized, then incorporated into a combinatorial library based on a peptidomimetic β-strand template. |
Publication details |
| Download |
http://espace.library.uq.edu.au/view/UQ:163054 |
| Publisher |
Pergamon Press/Elsevier
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| Repository |
ARROW Discovery Service (Australia) |
| Keywords |
Biologically Active Molecules (030401),
Organic Chemical Synthesis (030503),
Amino acids,
Peptides,
Pharmacology,
Chemistry, Medicinal,
Vaccines,
Serums
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| Type |
journal article
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| Relation |
isMemberOf Institute for Molecular Bioscience - Publications,
isMemberOf Excellence in Research Australia (ERA) - Collection
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