| Automatic annotation tools (2007) | |||||||||||||||||
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| The aim of a high-quality annotation is to identify the key genome features- in particular, the genes and their products in order to bridge the considerable gap between large-scale data-collection and its interpretation. The tools and resources for annotation are developing rapidly, however, high throughput data analysis requires the correct combination of these applications and databases. In this context we have developed different analysis tools for semi-automatical annotation of sequences. In collaboration with other NGFN/DHGP research groups we have designed tools supporting cDNA mapping and characterization of full length cDNAs (cDNA2Genome), semi-automatical analysis of EST sequences supporting the search of functional annotations of novel transcript sequences (ESTAnnotator), classification of protein sequences and inference of function, combining different classification and search methods of the commonly used protein family databases (Prosite, Prints, Pfam, Blocks, Smart, Prodom, Tigrfams), as well as Interpro and Gene Ontology (DomainSweep), protein secondary structure prediction (2Dsweep), etc... cDNA2Genome gives information about the chromosomal and contig location of the cDNA. It extracts the genomic sequence | |||||||||||||||||
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