| Dopamine release during sequential ®nger movements in health and Parkinson's disease: a PET study (2008) | |||||||||||||
Abstract | |||||||||||||
| Parkinson's disease is associated with slowness, especially of sequential movements, and is characterized pathologically by degeneration of dopaminergic neurons, particularly targeting nigrostriatal projections. In turn, nigrostriatal dopamine has been suggested to be critical for the execution of sequential movements. The objective of this study was to investigate in vivo, with [ 11 C]raclopride, PET changes in regional brain levels of dopamine in healthy volunteers and Parkinson's disease patients during the execution of paced, stereotyped sequential ®nger movements. Striatal [ 11 C]raclopride binding re¯ects dopamine D2 receptor availability and is in¯uenced by synaptic levels of endogenous dopamine. | |||||||||||||
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