| Sensitivity analysis of stoichiometric networks: an extension of Metabolic Control Analysis to non-equilibrium trajectories (2003) | |||||||||||||||
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| A sensitivity analysis of general stoichiometric networks is considered. The results are presented as a generalization of Metabolic Control Analysis, which has been concerned primarily with system sensitivities at steady state. An expression for time-varying sensitivity coefficients is given and the Summation and Connectivity Theorems are generalized. The results are compared to previous treatments. The analysis is accompanied by a discussion of the computation of the sensitivity coefficients and an application to a model of phototransduction. 1 | |||||||||||||||
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