| Stoichiometric redundancy: computational efficiencies and steady-state-consistent network reductions (2008) | |||||||||||||||||
Abstract | |||||||||||||||||
| The stoichiometry matrix is typically a redundant description of a metabolic network. It is shown that steady-state analysis of the network depends only on the form of these redundancies and so for such analysis much of the content of the stoichiometry matrix is irrelevant. As a result, existing analytic techniques can be streamlined. An additional consequence is that the stoichiometry matrix (and hence the network topology) can be modified without impacting the steady-state system description. This allows the construction of classes of networks which share the same stoichiometric properties. More importantly, it allows the identification of reduced versions of networks which are stoichiometrically consistent. By reducing internal reactions in this manner while retaining exchange fluxes, one arrives at a minimal description of a metabolic input/output module. | |||||||||||||||||
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