| Review Bayesian Analysis and Risk Assessment in Genetic Counseling and Testing (2008) | |||||||||||||
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| Risk assessment is an essential component of genetic counseling and testing, and Bayesian analysis plays a central role in genetic risk assessment. Bayesian analysis allows calculation of the probability of a particular hypothesis, either disease or carrier status, based on family information and/or genetic test results. Genetic risk should be assessed as accurately as possible for family decision making. Additional information, from the pedigree and/or from genetic testing, can often dramatically improve the accuracy of genetic risk assessment. We illustrate herein the application of Bayes ’ theorem and describe important basic principles in genetic risk assessment. (J Mol Diagn 2004, 6:1–9) The purpose of this article is to introduce basic and | |||||||||||||
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