| Database and comparison of non ribosomal peptides (2008) | |||||||||||||||||
Abstract | |||||||||||||||||
| Peptides are synthesized in bacteria or fungi not only through the classical pathway from the transcription of DNA to the translation of mRNA into peptides, but also through a ribosomeindependent pathway. This alternative pathway is called Non Ribosomal Peptide Synthesis (NRPS). It is performed by a huge protein complex called synthetase or NRPS (Non Ribosomal Peptide Synthetase). These are modularly organized multi-enzyme complexes which represent at the same time template and biosynthetic machinery. The molecules synthesized by NRPS are short (two to about fifty monomers), include a high density of non proteogenic amino acids and often contain amino acids connected by bounds other than peptide or disulfide bounds (for a review, see [1]). So the first dimension of the peptides synthesized is not always linear. It can forms cycles (partial or not) and it can exhibit branches. Those peptides have interesting biological properties such as immunomodulating, iron chelating or antibiotic activities, as illustrated by the famous antibiotic penicillin which is synthesized from ACV-tripeptide precursor produced by the NRPS pathway. The construction of a database with all known NRPS synthesized peptides should represent a good tool to study these products. To our knowledge, such a database is not available, except “a knowledge based resource for analysis of | |||||||||||||||||
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