| Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular disease (2008) | |||||||||||
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| Endothelial dysfunction underlies cardiovascular disease (CVD) in humans and is reported in animal models of developmental origins of such disease. We have investigated whether impaired antioxidant defences and NO generation underlie the genesis of endothelial dysfunction and operate as part of the normal processes of developmental plasticity regulating the induction of phenotype in the offspring. Female Wistar rats were fed either a control (C, 18% protein) or protein-restricted (PR, 9% protein) diet throughout pregnancy. Dams and pups were returned to standard laboratory chow postpartum. In male offspring, PR resulted in a reduced endothelial responsiveness to acetylcholine (p | |||||||||||
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