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Identification of loci associated with schizophrenia by genome-wide association and follow-up (2008) |
- Donovan, Michael C.,
- Craddock, Nicholas,
- Norton, Nadine,
- Williams, Hywel,
- Peirce, Timothy,
- Moskvina, Valentina,
- Nikolov, Ivan,
- Hamshere, Marian,
- Carroll, Liam,
- Georgieva, Lyudmila,
- Dwyer, Sarah,
- Holmans, Peter,
- Marchini, Johnthan L.,
- Spencer, Chris C. A.,
- Howie, Bryan,
- Leung, Hin-Tak,
- Hartmann, Annette M.,
- Moller, Hans-Jurgen,
- Morris, Derek W.,
- Shi, YongYong,
- Feng, GuoYin,
- Hoffmann, Per,
- Propping, Peter,
- Vasilescu, Catalina,
- Maier, Wolfgang,
- Rietschel, Marcella,
- Zammit, Stanley,
- Schumacher, Johannes,
- Quinn, Emma M.,
- Schulze, Thomas G.,
- Williams, Nigel M.,
- Giegling, Ina,
- Iwata, Nakao,
- Ikeda, Masashi,
- Darvasi, Ariel,
- Shifman, Sagiv,
- He, Lin,
- Duan, Jubao,
- Sanders, Alan R.,
- Levinson, Douglas F.,
- Gejman, Pablo V.,
- Cichon, Sven,
- No¨then, Markus M.,
- Gill, Michael,
- Corvin, Aiden,
- Rujescu, Dan,
- Kirov, George,
- Owen, Michael J.,
- Mowry, Bryan
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Abstract |
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We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 10-9). |
Publication details |
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