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Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart (2005) |
- Heymans, Stephane; U0011145,
- Schroen, B,
- Vermeersch, Pieter; U0035259,
- Milting, H,
- Gao, FY,
- Kassner, A,
- Gillijns, Hilde; U0001751,
- Herijgers, Paul; U0010444,
- Flameng, Willem; U0018951,
- Carmeliet, Peter; U0021003,
- De Werf, FV,
- Pinto, YM,
- Janssens, S
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Abstract |
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Background - Alterations in the balance of matrix metalloproteinases ( MMPs) and their specific tissue inhibitors (TIMPs) are involved in left ventricular (LV) remodeling. Whether their expression is related to interstitial fibrosis or LV dysfunction in patients with chronic pressure overload - induced LV hypertrophy, however, is unknown. |
Publication details |
| Download |
http://gateway.newisiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=CCC&SrcApp=PRODUCT_NAME&SrcURL=WOS_RETURN_URL&CKEY=HEYM1136050112CS&DestLinkType=FullRecord&DestApp=CCC&SrcDesc=RETURN_ALT_TEXT&SrcAppSID=APP_SID |
| Publisher |
Lippincott williams & wilkins
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| Repository |
Lirias is a research document repository at KULeuven (Belgium) |
| Keywords |
metalloproteinases,
remodeling,
hypertrophy,
hypertension,
collagen,
matrix gene-expression,
aortic-valve disease,
diastolic dysfunction,
myocardial-infarction,
failure,
hypertrophy,
rats,
replacement,
progression,
mechanisms
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| Type |
Description (Metadata) only,
IT,
article
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| Language |
English
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| Relation |
Circulation vol:112 issue:8 pages:1136-1144
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