| Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia (2007) | |||||||||||||||
Abstract | |||||||||||||||
| We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL. | |||||||||||||||
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