| Identifying novel constrained elements by exploiting biased substitution patterns | |||||||||||||
Abstract | |||||||||||||
| Motivation: Comparing the genomes from closely related species provides a powerful tool to identify functional elements in a reference genome. Many methods have been developed to identify conserved sequences across species; however, existing methods only model conservation as a decrease in the rate of mutation and have ignored selection acting on the pattern of mutations. | |||||||||||||
Publication details | |||||||||||||
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