| Analysis Transcriptional control of human p53-regulated genes (2009) | |||||||||||||||
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| Abstract | The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation. Response element A short sequence of DNA in or near a gene that can bind one or more transcription factors that can regulate the transcriptional activity of that gene. Extracellular matrix The complex, multi-molecular material that surrounds cells. It comprises a scaffold on which tissues are organized, provides cellular microenvironments and regulates various cellular functions. | |||||||||||||||
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