| Increased concentrations of L-lactate in the rectal lumen in patients undergoing cardiopulmonary bypass (2005) | |||||||||||||
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| Background. Gut ischaemia may contribute to morbidity in patients after cardiopulmonary bypass (CPB), but little is known about the metabolic state of the large bowel in such patients. Therefore we estimated the concentrations of l-lactate and Pco2 in rectal mucosa in patients undergoing cardiac surgery with or without the use of CPB. Methods. Patients undergoing coronary artery bypass grafting (CABG) (n=12) or off-pump CABG (n=10) were subjected to equilibrium dialysis of the rectal lumen during the procedure and in the first 4 h afterwards. Dialysate concentrations of l-lactate and Pco2 were measured using an auto-analyser and compared with values obtained in healthy subjects (n=10). Results. During CPB, a 2- to 3-fold increase in luminal concentrations of l-lactate was observed (CABG vs off-pump CABG, P=0.05; CABG vs healthy subjects, P | |||||||||||||
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